/* ═══════════════════════════════════════════════════════════════
   OmicsLab — Pharmacogenomics Africa CSS
   ═══════════════════════════════════════════════════════════════ */

.pgx-page { max-width: 1200px; margin: 0 auto; padding: 2.5rem 1.5rem 5rem; }

.pgx-header { text-align: center; margin-bottom: 2rem; }
.pgx-title {
  font-size: clamp(1.5rem, 3vw, 2.2rem); font-weight: 800;
  background: linear-gradient(135deg, #f97316, #e3b341);
  -webkit-background-clip: text; -webkit-text-fill-color: transparent; background-clip: text;
  margin: 0 0 0.4rem;
}
.pgx-subtitle { font-size: 0.88rem; color: var(--text-muted, #8b949e); margin: 0; }

/* Summary stats */
.pgx-summary-row {
  display: grid; grid-template-columns: repeat(4, 1fr); gap: 0.8rem; margin-bottom: 2rem;
}
.pgx-summary-card {
  background: var(--bg-card, #161b22); border: 1px solid #21262d;
  border-top: 3px solid; border-radius: 10px; padding: 1rem;
}
.pgx-summary-stat { font-size: 1.5rem; font-weight: 800; font-family: var(--font-mono, monospace); }
.pgx-summary-label { font-size: 0.78rem; color: #c9d1d9; margin: 0.25rem 0 0.15rem; }
.pgx-summary-note { font-size: 0.7rem; color: #8b949e; }

/* Filter */
.pgx-filter-row {
  display: flex; align-items: center; gap: 0.5rem; margin-bottom: 1.5rem; flex-wrap: wrap;
}
.pgx-filter-label { font-size: 0.78rem; color: #8b949e; white-space: nowrap; }
.pgx-cat-btn {
  padding: 0.3rem 0.75rem; border-radius: 20px; border: 1px solid #30363d;
  background: transparent; color: #8b949e; cursor: pointer; font-size: 0.75rem; font-weight: 600;
  transition: all 0.2s;
}
.pgx-cat-btn:hover { border-color: #f97316; color: #c9d1d9; }
.pgx-cat-btn.active { background: rgba(249,115,22,0.12); border-color: #f97316; color: #f97316; }

/* Layout */
.pgx-layout { display: grid; grid-template-columns: 220px 1fr; gap: 1.5rem; margin-bottom: 3rem; }

/* Sidebar */
.pgx-gene-sidebar { display: flex; flex-direction: column; gap: 0; }
.pgx-sidebar-title {
  font-size: 0.72rem; font-weight: 700; text-transform: uppercase; letter-spacing: 0.07em;
  color: #8b949e; margin-bottom: 0.5rem;
}
.pgx-gene-btn {
  display: block; width: 100%; text-align: left; padding: 0.65rem 0.85rem;
  border: 1px solid transparent; border-radius: 8px; background: transparent;
  cursor: pointer; margin-bottom: 0.35rem; transition: all 0.18s;
}
.pgx-gene-btn:hover { background: rgba(255,255,255,0.04); }
.pgx-gene-name { font-weight: 800; font-size: 0.92rem; font-family: var(--font-mono, monospace); }
.pgx-gene-func { font-size: 0.68rem; color: #8b949e; margin-top: 0.15rem; }

/* Detail panel */
.pgx-detail-panel {
  background: var(--bg-card, #161b22); border: 1px solid #21262d;
  border-radius: 14px; padding: 1.5rem; min-height: 400px;
}
.pgx-empty {
  display: flex; align-items: center; justify-content: center;
  height: 200px; color: #8b949e; font-size: 0.85rem; text-align: center;
  max-width: 400px; margin: 0 auto; line-height: 1.6;
}
.pgx-detail-header {
  padding-bottom: 0.85rem; border-bottom: 2px solid; margin-bottom: 1rem;
}
.pgx-detail-gene { font-size: 1.6rem; font-weight: 900; font-family: var(--font-mono, monospace); }
.pgx-detail-fullname { font-size: 0.85rem; color: #c9d1d9; margin-top: 0.1rem; }
.pgx-detail-function { font-size: 0.75rem; color: #8b949e; margin-top: 0.1rem; font-style: italic; }

.pgx-summary-box {
  background: rgba(255,255,255,0.03); border: 1px solid;
  border-radius: 8px; padding: 0.85rem 1rem; font-size: 0.82rem;
  color: #c9d1d9; line-height: 1.65; margin-bottom: 1.25rem;
}

.pgx-section-title {
  font-size: 0.72rem; font-weight: 700; text-transform: uppercase;
  letter-spacing: 0.07em; color: #8b949e; margin-bottom: 0.5rem;
}

.pgx-table-wrap { overflow-x: auto; border-radius: 8px; border: 1px solid #21262d; }
.pgx-table {
  width: 100%; border-collapse: collapse; font-size: 0.78rem;
}
.pgx-table th {
  padding: 0.5rem 0.75rem; text-align: left; font-size: 0.68rem;
  font-weight: 700; text-transform: uppercase; letter-spacing: 0.05em;
  color: #8b949e; border-bottom: 1px solid #30363d; background: #0d1117;
  white-space: nowrap;
}
.pgx-table td {
  padding: 0.55rem 0.75rem; border-bottom: 1px solid #21262d; color: #8b949e;
  vertical-align: middle;
}
.pgx-table tbody tr:last-child td { border-bottom: none; }
.pgx-table tbody tr:hover { background: rgba(255,255,255,0.03); }

.pgx-cat-badge {
  padding: 0.18rem 0.5rem; border-radius: 20px; font-size: 0.68rem;
  font-weight: 700; white-space: nowrap;
}
.pgx-level { font-weight: 700; font-size: 0.72rem; white-space: nowrap; }

.pgx-africa-note {
  margin-top: 1.25rem; padding: 0.85rem 1rem;
  background: rgba(63,185,80,0.06); border-radius: 8px; border-left: 3px solid #3fb950;
}
.pgx-africa-note-title {
  font-size: 0.72rem; font-weight: 700; text-transform: uppercase;
  letter-spacing: 0.07em; color: #3fb950; margin-bottom: 0.4rem;
}
.pgx-africa-note { font-size: 0.8rem; color: #c9d1d9; line-height: 1.6; }

/* Resources */
.pgx-resources { border-top: 1px solid #21262d; padding-top: 2rem; }
.pgx-resources-title {
  font-size: 0.78rem; font-weight: 700; text-transform: uppercase;
  letter-spacing: 0.07em; color: #8b949e; margin-bottom: 1rem;
}
.pgx-resource-grid { display: grid; grid-template-columns: repeat(auto-fill, minmax(180px, 1fr)); gap: 0.75rem; }
.pgx-resource-card {
  background: var(--bg-card, #161b22); border: 1px solid #21262d;
  border-radius: 8px; padding: 0.75rem;
  transition: border-color 0.2s;
}
.pgx-resource-card:hover { border-color: #f97316; }
.pgx-resource-name { font-weight: 700; color: #f97316; font-size: 0.82rem; margin-bottom: 0.25rem; }
.pgx-resource-desc { font-size: 0.72rem; color: #8b949e; line-height: 1.45; }

@media (max-width: 860px) {
  .pgx-summary-row { grid-template-columns: repeat(2, 1fr); }
  .pgx-layout { grid-template-columns: 1fr; }
  .pgx-gene-sidebar { display: grid; grid-template-columns: repeat(3, 1fr); gap: 0.4rem; }
  .pgx-sidebar-title { grid-column: 1/-1; }
}
@media (max-width: 520px) {
  .pgx-summary-row { grid-template-columns: 1fr 1fr; }
  .pgx-gene-sidebar { grid-template-columns: repeat(2, 1fr); }
  .pgx-page { padding: 1.5rem 1rem 3rem; }
}